Protein Modification Reagents
eMolecules 459426-22-3 | Medchem Express | Biotin-PEG4-NHS ester | 50mg | 527574014 | HY-140889 | MFCD08458915 | 588.67 | C25H40N4O10S
Ambeed | (S)-tert-Butyl 2-methylpiperazine-1-carboxylate hydrochloride | 1g | 552587486 | A149133 | 960283-58-3 | MFCD11101258 | 236.740 | C10H21ClN2O2
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Medchemexpress LLC DSPE-PEG-folate | 90.0% | 2000 (Average) | 5 MG
DSPE-PEG-folate (average MW 2000) is a PEGylated lipid conjugate in which a DSPE lipid is linked to polyethylene glycol terminating in folate. Supplied as a solid powder for research use, it is used to introduce folate targeting moieties onto liposomes, micelles, and nanoparticle surfaces to enable receptor-mediated delivery to folate receptor-expressing cells. Typical storage: powder at -20°C; in solvent store at -80°C for long-term stability.
- Provides folate-mediated targeting to folate receptor-expressing cells.
- Suitable for incorporation into liposomes, micelles, and nanoparticle surfaces.
- Average molecular weight approximately 2000 Da.
- Supplied as a solid powder for laboratory research use.
- Purity approximately 90.0% as provided by the manufacturer.
- Storage recommendations included for powder and in-solution conditions.
Medchemexpress LLC HS-PEG5-CH2CH2NH2 hydrochloride | 1446256-16-1 | 98.0% | C12H28ClNO5S | 10MG
HS-PEG5-CH2CH2NH2 hydrochloride is a thiol-terminated PEG5 linker supplied as the hydrochloride salt, intended for synthesis of PROTACs and other bioconjugates. It provides a short, flexible spacer with terminal thiol and amine groups for versatile conjugation chemistries.
- Thiol-terminated PEG5 linker for conjugation chemistries.
- Terminal ethyleneamine available as hydrochloride salt.
- Short, flexible spacer suitable for PROTAC design.
- High purity (98.0%) for consistent synthetic performance.
- Compatible with common bioconjugation reactions.
Medchemexpress LLC Cyanine 5-polyethylene glycol3-TCO | 99.2% | 845.55 | C49H69ClN4O6 | 10 MG
Cy5-PEG3-TCO is a Cy5-derived fluorescent probe bearing a three-unit polyethylene glycol (PEG3) spacer and a trans-cyclooctene (TCO) functional group. It is designed for bioorthogonal labeling via inverse electron-demand Diels-Alder (iEDDA) reactions with tetrazine-functionalized partners and is supplied as a solid for laboratory use.
- Cyanine 5 fluorescent core for near-infrared imaging
- PEG3 spacer improves solubility and reduces steric hindrance
- TCO group enables rapid iEDDA click chemistry with tetrazines
- High purity (99.2%) suitable for labeling applications
- Soluble in DMSO (≈16.67 mg/mL); may require ultrasonic
- Stored sealed away from moisture and light at 4°C (solid)
Medchemexpress LLC Dbco-(PEG2-VC-PAB-MMAE)2 | 2259318-55-1 | 99.2% | 2,835.50 g/mol | C149H224N22O32 | 50 MG
DBCO-(PEG2-VC-PAB-MMAE)2 is a drug-linker conjugate for antibody-drug conjugate (ADC) research that combines a DBCO reactive group with a cleavable valine-citrulline linker, a p-aminobenzyl self-immolative spacer, and dual MMAE payloads. It is supplied as a purified powder for use in bio-conjugation via strain-promoted alkyne-azide cycloaddition (SPAAC).
- Provides a DBCO reactive group for copper-free click chemistry (SPAAC).
- Includes a PEG2 spacer for improved solubility and flexibility.
- Features a valine-citrulline cleavable linker with a p-aminobenzyl self-immolative spacer.
- Contains two MMAE payloads for potent cytotoxic delivery.
- High purity, typically 99.2%.
- Supplied as a powder suitable for ADC construction and conjugation.
Medchemexpress LLC Tos-PEG4-NH-Boc (PROTAC Linker 7) | 1246999-33-6 | >98.0% | 100 MG
Tos-PEG4-NH-Boc (PROTAC Linker 7) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based linker.
- Used in the synthesis of PROTACs.
- Connects two different ligands.
- Exploits the intracellular ubiquitin-proteasome system.
- Selectively degrades target proteins.
Medchemexpress LLC Amino-PEG5-CH2COOH | 141282-35-1 | ≥97.0% | 250 MG
Amino-PEG5-CH2COOH is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs (proteolysis-targeting chimeras) exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. They function by connecting a ligand for an E3 ubiquitin ligase with a ligand for the target protein.
- PEG-based PROTAC linker
- Used for synthesizing PROTACs
- Facilitates selective degradation of target proteins
- Molecular weight: 295.33
- Chemical formula: C12H25NO7
- Appearance: Solid
- Color: White to off-white
TARGETMOL CHEMICALS INC DBCO-PEG4-NHS ESTER 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. DBCO-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in PROTAC synthesis[1]. purity: 95%
Medchemexpress LLC Methyl-PEG4 N-hydroxysuccinimide ester | 622405-78-1 | MFCD11041112 | 95.0% | 333.33 | C14H23NO8 | 1G
M-PEG4-NHS ester is a methyl-terminated polyethylene glycol (PEG) linker bearing an N-hydroxysuccinimide (NHS) ester. It is intended for bioconjugation and medicinal chemistry applications, including PROTAC synthesis and amine labeling, where an amine-reactive spacer that improves solubility and enables stable amide bond formation is required.
- Provides an NHS ester for efficient coupling to primary amines.
- Methyl-terminated PEG4 spacer improves solubility and reduces steric hindrance.
- Molecular weight 333.33 and formula C14H23NO8.
- Typical purity 95.0% suitable for synthetic applications.
- Available in multiple pack sizes, including 1 g.